Dysregulated hemostatic mechanisms often lead to hyperaggregation of activated platelets and overaction of coagulation events, ultimately leading to occlusive clot formation. Such occlusive clotting is a primary characteristic in many vascular disease conditions, leading to ischemia, unstable angina, myocardial infarction, stroke etc. Such conditions lead to significant tissue morbidity and mortality, and hence dissolving or removing the clot rapidly to re-establish blood flow to critical tissues and organs remains a clinical mainstay in treating these conditions. The mechanical strategies for clot removal include thrombectomy or angioplasty (with or without stenting) which are invasive and can cause secondary injuries and thrombotic events, leading to re-occlusion.

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