Platelets are megakaryocyte-derived enucleated blood cells that are primarily responsible for hemostasis (staunching bleeding) in the body. Platelets render hemostasis by marginating across bulk blood flow towards the vascular injury site, adhering to the site via molecular interactions with specific proteins (e.g. vWF and collagen), undergoing activation as an effect of adhesion-induced signaling, secreting platelet agonists (e.g. ADP and thrombin) to further locally activate other platelets and promoting aggregation of these activated platelets via inter-platelet bridging mediated by ligand interactions with platelet surface integrins and selectins.

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