Interaction of biomedical devices and implants with the living tissue is largely mediated by surface chemistry and surface morphology. For example, for blood-contacting devices (vascular grafts, wound healing systems, dialysis membranes etc.), protein adhesion, denaturation and retention on the device surface dictates the long term favorable or unfavorable cellular interactions with the device. For bio-inspired devices or tissue engineered constructs, often specific cell-material interactions are required for intended property and functions. To this end, our laboratory develops and studies variety of physical and chemical surface modification technologies for preventing or promoting specific protein-material and cell-material interactions.